Publication Name	World Journal of Transplantation
Manuscript ID	116413
Country	India

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Influence of islet purity on the proportion of smaller islets and graft outcomes in clinical transplantation
Manuscript Source	Invited Manuscript
All Author List	Praveen Kumar Ravi, Sipra Rout, Pravash R Mishra and Appakalai N Balamurugan
Funding Agency and Grant Number
Corresponding Author	Praveen Kumar Ravi, Assistant Professor, MD, Department of Anatomy, All India Institute of Medical Sciences, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. praveenkumar1059@gmail.com
Key Words	Islets of langerhans transplantation; Purification; Islet size; Engraftment; Insulin independence
Core Tip	The interaction between islet purity and size distribution influences the results of islet transplantation in addition to islet volume. Highly purified preparation prevents the adverse reaction, but it also decreases the small islets proportion and supportive progenitor cells from the preparation. Reduction in small islets leading to overestimation of the islet transplanted, reduced graft viability and function. Smaller islets demonstrate superior survival, revascularization, and insulin secretion, since it survives better with diffusion when compared with larger islets. Hence, moderate rather than maximal purification may preserve small islets, paracrine support, and regenerative potential, improving long-term engraftment and insulin independence.
Citation	Ravi PK, Rout S, Mishra PR, Balamurugan AN. Influence of islet purity on the proportion of smaller islets and graft outcomes in clinical transplantation. World J Transplant 2026; In press

Received	2025-11-12 06:17
Peer-Review Started	2025-11-12 06:17
First Decision by Editorial Office Director	2025-12-16 09:13
Return for Revision	2025-12-16 09:13
Revised	2025-12-20 12:35
Publication Fee Transferred
Second Decision by Editor	2026-02-11 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 10:41
Articles in Press	2026-02-11 10:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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