Publication Name	World Journal of Gastroenterology
Manuscript ID	116415
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Retrospective Study
Article Title	Development and validation of prognostic models for colon cancer incorporating extramural vascular invasion assessed by contrast-enhanced computed tomography
Manuscript Source	Unsolicited Manuscript
All Author List	Mei-Rong Wang, Liang-Fang Zheng, Fan Yang, Xiao-Yu Gu, Ju-Shun Yang, Fei-Xiang Chen, Jia-Min Liu and Bo-Sheng He
Funding Agency and Grant Number	Funding Agency Grant Number Nantong University Special Research Fund for Clinical Medicine No. 2024LQ022 Jiangsu Commission of Health No. ZD2021059 Nantong Municipal Commission of Health and Family Planning No. QA2020002
Corresponding Author	Bo-Sheng He, PhD, Department of Radiology, Nantong First People’s Hospital, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. boshenghe@126.com
Key Words	Colon cancer; Computed tomography-detected extramural vascular invasion; Disease-free survival; Machine learning; Nomogram
Core Tip	Extramural vascular invasion represents a well-established determinant of prognosis in colon cancer; however, its reliable evaluation before surgery remains clinically challenging. The present study provided evidence that computed tomography-detected extramural vascular invasion (ctEMVI) functioned as an independent predictor of disease-free survival following curative resection. By incorporating ctEMVI with conventional clinicopathological factors, we developed interpretable machine-learning-based prediction models and a nomogram to enhance individualized preoperative risk assessment. Among the evaluated algorithms, CoxBoost demonstrated the strongest predictive capability. Collectively, these results underscored the clinical utility of ctEMVI-driven modeling approaches for refining preoperative risk stratification in patients with colon cancer.
Citation	Wang MR, Zheng LF, Yang F, Gu XY, Yang JS, Chen FX, Liu JM, He BS. Development and validation of prognostic models for colon cancer incorporating extramural vascular invasion assessed by contrast-enhanced computed tomography. World J Gastroenterol 2026; In press

Received	2025-11-17 12:13
Peer-Review Started	2025-11-18 03:03
First Decision by Editorial Office Director	2025-12-11 10:11
Return for Revision	2025-12-11 10:11
Revised	2025-12-23 08:28
Publication Fee Transferred	2025-12-26 14:41
Second Decision by Editor	2026-02-03 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 04:22
Articles in Press	2026-02-03 04:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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