Publication Name	World Journal of Gastroenterology
Manuscript ID	116425
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond monotherapy by acid suppression: Reshaping the management of refractory gastroesophageal reflux disease
Manuscript Source	Invited Manuscript
All Author List	Xin-Ye Zuo and Qian-Qian Chen
Funding Agency and Grant Number	Funding Agency Grant Number General Program of Municipal Natural Science Foundation of Beijing 7232151
Corresponding Author	Qian-Qian Chen, Professor, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. qian_qian_chen@163.com
Key Words	Refractory gastroesophageal reflux disease; Anxiety; Holistic medicine; Endoscopic intervention; Multidisciplinary management
Core Tip	A recent Shanghai study identified prolonged disease duration and anxiety as key risk factors for refractory gastroesophageal reflux disease, whereas moderate physical activity is protective. Management should extend beyond standard acid suppression to include a “multidimensional” strategy incorporating anti-anxiety interventions, exercise prescriptions, and multidisciplinary collaboration. However, the study’s single-region sample and cross-sectional design necessitate future multi-regional, long-term research to validate and establish causality.
Citation	Zuo XY, Chen QQ. Beyond monotherapy by acid suppression: Reshaping the management of refractory gastroesophageal reflux disease. World J Gastroenterol 2025; In press

Received	2025-11-11 12:03
Peer-Review Started	2025-11-11 12:03
First Decision by Editorial Office Director	2025-11-30 02:16
Return for Revision	2025-11-30 02:16
Revised	2025-12-11 02:37
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 09:50
Articles in Press	2025-12-25 09:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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