Publication Name	World Journal of Psychiatry
Manuscript ID	116428
Country	China

Category	Psychology, Clinical
Manuscript Type	Observational Study
Article Title	Bridging the gap between subjective and objective measures: A multimodal protocol for adolescent depression detection
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Zeng, Jian Yang and Li Kuang
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Science and Health Joint Medical Research Project 2021MSXM034 Natural Science Foundation of Xizang Autonomous Region XZ2024ZR-ZY100(Z) Program for Youth Innovation in Future Medicine, Chongqing Medical University, China W0138 Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University CMER202305
Corresponding Author	Li Kuang, Chief Physician, Professor, Department of Psychology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. kuangli0388@126.com
Key Words	Adolescent depression; Multimodal detection; Facial expression; Vocal prosody; Machine learning; Extreme gradient boosting
Core Tip	Current screening for adolescent depression relies heavily on subjective questionnaires. To address this, we developed a multimodal protocol combining the Chinese Secondary School Students Depression Scale with objective facial and vocal data to improve detection. Our analysis showed that extreme gradient boosting outperformed other machine learning models under both multimodal and bimodal settings, achieving superior performance across multiple metrics. Statistical comparisons confirmed that the multimodal extreme gradient boosting model significantly surpassed its bimodal counterpart, demonstrating the advantage of integrating subjective scales with objective data to enhance the accuracy and robustness of depression screening in Chinese adolescents. Further validation in diverse populations is warranted.
Citation	Zeng Y, Yang J, Kuang L. Bridging the gap between subjective and objective measures: A multimodal protocol for adolescent depression detection. World J Psychiatry 2026; In press

Received	2025-11-12 08:08
Peer-Review Started	2025-11-12 08:21
First Decision by Editorial Office Director	2025-11-28 06:31
Return for Revision	2025-11-28 06:31
Revised	2025-12-07 16:16
Publication Fee Transferred	2025-12-08 17:40
Second Decision by Editor	2026-01-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 05:57
Articles in Press	2026-01-14 05:57
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Typeset the Manuscript

ISSN	2220-3206 (online)
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