Publication Name	World Journal of Diabetes
Manuscript ID	116477
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	Glucagon-like peptide-1 receptor agonists in type 2 diabetes: Evidence for disease modification and therapeutic switching
Manuscript Source	Invited Manuscript
All Author List	Vanishri Ganakumar, Cornelius J Fernandez and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, MRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, All Saints Building, Oxford Road, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Glucagon-like peptide-1 receptor agonists; Incretin polyagonists; Type 2 diabetes mellitus; Switching glucagon-like peptide-1 receptor agonist; Glycemic control
Core Tip	Pharmacological manipulation of the incretin system has revolutionised the management of type 2 diabetes mellitus (T2DM) in the 21st century. The first few drug molecules in this group were the glucagon-like peptide-1 receptor agonists (GLP-1RA), which have been used for treating patients with T2DM in the past 2 decades. Newer molecules, including incretin polyagonists, with longer half-lives and dosing intervals, and better cardiometabolic outcomes, are being added recently. A study by Kassem et al published in the World Journal of Diabetes provides us with robust evidence from a large real-world study from Israel on the benefits of switching from an old GLP-1RA to a newer agent, the theme of this editorial.
Citation	Ganakumar V, Fernandez CJ, Pappachan JM. Glucagon-like peptide-1 receptor agonists in type 2 diabetes: Evidence for disease modification and therapeutic switching. World J Diabetes 2026; In press

Received	2025-11-12 02:09
Peer-Review Started	2025-11-12 05:45
First Decision by Editorial Office Director	2025-12-11 08:13
Return for Revision	2025-12-11 08:13
Revised	2025-12-12 18:50
Publication Fee Transferred
Second Decision by Editor	2026-01-12 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 09:21
Articles in Press	2026-01-12 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com