Publication Name	World Journal of Psychiatry
Manuscript ID	116515
Country	China

Category	Psychiatry
Manuscript Type	Editorial
Article Title	Toward a psychoneuroimmune interpretation of anxiety and depression risk in cervical cancer
Manuscript Source	Invited Manuscript
All Author List	Huan-Fang Fan, Jia Yuan and De-Hui Li
Funding Agency and Grant Number	Funding Agency Grant Number 2023 Government-funded Project of the Outstanding Talents Training Program in Clinical Medicine No. ZF2023165 Key Research and Development Projects of Hebei Province No. 18277731D Natural Science Foundation of Hebei Province No. H2024423105 Hebei Provincial Administration of Traditional Chinese Medicine, Scientific Research Project No. 2023045 Hebei Provincial Administration of Traditional Chinese Medicine, Scientific Research Project No. 2024023 Hebei Institute of Traditional Chinese Medicine Pharmaceutical Preparation Industry Technology Special Project No. YJY2024006 Scientific Research Project of Health Commission of Hebei Province No. 20220962 Scientific Research Project of Health Commission of Hebei Province No. 20240282
Corresponding Author	De-Hui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), No. 389 Zhongshan East Road, Chang‘an District, Shijiazhuang 050000, Hebei Province, China. 258289951@qq.com
Key Words	Psycho-neuro-immune axis; Cervical cancer; Anxiety; Depression; Clinical predictive model; Mechanism
Core Tip	This commentary elucidates the innovative “psycho-neuro-immune” axis mechanism underlying a predictive model for anxiety/depression in cervical cancer. The four distinct risk factors, such as advanced cancer, comprehensive therapy, low hope level, and low income level, converge via the psycho-neuro-immune axis: Physical stressors trigger an “outside-in” immune-to-brain pathway, while psychosocial stressors drive a “top-down” neuroendocrine-to-immune pathway. These pathways interact, creating a vicious cycle that sustains peripheral and central inflammation, ultimately leading to mood symptoms. This integrative framework transforms clinical risk prediction into a targetable biological model for future interventions.
Citation	Fan HF, Yuan J, Li DH. Toward a psychoneuroimmune interpretation of anxiety and depression risk in cervical cancer. World J Psychiatry 2026; In press

Received	2025-11-13 04:56
Peer-Review Started	2025-11-13 09:12
First Decision by Editorial Office Director	2025-12-17 08:00
Return for Revision	2025-12-17 08:00
Revised	2026-01-10 08:18
Publication Fee Transferred
Second Decision by Editor	2026-02-11 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 04:08
Articles in Press	2026-02-11 04:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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