Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	116518
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Reduction of serum bilirubin levels after endoscopic biliary drainage in patients with extrahepatic biliary obstruction and its significance
Manuscript Source	Invited Manuscript
All Author List	Kosuru Sham Charan Naidu, Suprabhat Giri, Saroj Kanta Sahu, Dibya Lochan Praharaj, Bipadabhanjan Mallick, Preetam Nath, Swati Das, Sarat Chandra Panigrahi, Manoj Kumar Sahu, Anil Chandra Anand, Yogesh K Chawla and Subrat Kumar Acharya
Funding Agency and Grant Number
Corresponding Author	Bipadabhanjan Mallick, Professor, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Kushabhadra Campus, 5 KIIT Road, Patia, Bhubaneswar 751024, Odisha, India. bipada.mallick@kims.ac.in
Key Words	Endoscopic retrograde cholangiopancreatography; Extrahepatic biliary obstruction; Endoscopic biliary drainage; Malignant biliary obstruction; Choledocholithiasis
Core Tip	Early bilirubin kinetics provide a simple, reliable, and clinically actionable tool after endoscopic biliary drainage for extrahepatic biliary obstruction. A ≥ 50% fall in bilirubin by day 7 indicates adequate drainage and predicts lower need for reintervention, whereas failure should prompt early reassessment for stent dysfunction or incomplete drainage. Achieving a bilirubin < 3 mg/dL by day 15 is a strong indicator of recovery, particularly in malignant obstruction; failure to do so predicts higher short-term mortality. Baseline bilirubin, alkaline phosphatase levels, etiology, and presence of acute kidney injury should guide the intensity of monitoring. Routine incorporation of bilirubin kinetics can improve post-endoscopic retrograde cholangiopancreatography decision-making and outcomes.
Citation	Naidu KSC, Giri S, Sahu SK, Praharaj DL, Mallick B, Nath P, Das S, Panigrahi SC, Sahu MK, Anand AC, Chawla YK, Acharya SK. Reduction of serum bilirubin levels after endoscopic biliary drainage in patients with extrahepatic biliary obstruction and its significance. World J Gastrointest Endosc 2026; In press

Received	2025-11-14 08:14
Peer-Review Started	2025-11-14 08:21
First Decision by Editorial Office Director	2025-11-25 08:01
Return for Revision	2025-11-25 08:01
Revised	2025-12-03 17:44
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-06 10:33
Articles in Press	2026-01-06 10:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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