Publication Name	World Journal of Stem Cells
Manuscript ID	116526
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats
Manuscript Source	Unsolicited Manuscript
All Author List	Lu-Yao Han, Wen-Zhu Zhang, Yu Zhang, Wan Zhong, Jing-Li Sun and Jian Shen
Funding Agency and Grant Number	Funding Agency Grant Number Shenyang Science and Technology Plan in 2022 22-321-32-16
Corresponding Author	Jian Shen, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), No. 5 Guangrong Street, Heping District, Shenyang 110000, Liaoning Province, China. shenjian99@sina.com
Key Words	Human amniotic epithelial cells; Human umbilical cord blood mesenchymal stem cells; Preeclampsia; Exosomes; Vascular endothelial growth factor; Placental growth factor
Core Tip	Preeclampsia (PE) is a serious obstetric syndrome, and effective therapeutic options are required urgently. This study demonstrates that exosomes derived from human amniotic epithelial cells and umbilical cord mesenchymal stem cells can function as innovative cell-free agents. Treatment with these exosomes effectively ameliorated key pathological features, including hypertension, proteinuria, and placental damage, in a rat model of PE. The underlying mechanisms involve multi-target modulation of angiogenic and inflammatory pathways. These findings highlight the clinical translation potential of exosomes derived from human amniotic epithelial cells and umbilical cord mesenchymal stem cells as novel therapeutic strategies for PE.
Citation	Han LY, Zhang WZ, Zhang Y, Zhong W, Sun JL, Shen J. Therapeutic effects of human amniotic epithelial cell-derived and umbilical cord blood mesenchymal stem cell-derived exosomes on preeclamptic rats. World J Stem Cells 2026; In press

Received	2025-11-28 09:55
Peer-Review Started	2025-11-28 09:55
First Decision by Editorial Office Director	2025-12-18 09:10
Return for Revision	2025-12-18 09:10
Revised	2025-12-31 13:41
Publication Fee Transferred	2026-01-09 03:43
Second Decision by Editor	2026-03-25 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-25 09:41
Articles in Press	2026-03-25 09:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com