Publication Name	World Journal of Gastroenterology
Manuscript ID	116527
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Chao Gu, Xin Li, Yuan-Jun Zhao, Tao Wu, Cheng-Guo Zhou, Wen-Liang Hu, Zhi-Wei Fu, Jian-Hao Huang and Zi-Yang Ren
Funding Agency and Grant Number
Corresponding Author	Ying-Chao Gu, Department of General Surgery, Dazhou Dachuan District People’s Hospital (Dazhou Third People’s Hospital), No. 700 Hanxing North Street, Sanliping Street, Dachuan District, Dazhou 635711, Sichuan Province, China. guyingchao2@163.com
Key Words	Yin Yang 1-associated protein 1; Gastric adenocarcinoma; Tumor proliferation; Oncogene; Prognostic biomarker
Core Tip	This study identifies Yin Yang 1-associated protein 1 (YY1AP1) as an independent prognostic biomarker in gastric cancer. We demonstrate that high YY1AP1 expression, linked to tumor progression and poor survival, promotes cancer cell proliferation and migration by modulating p21, c-myc, and snail pathways. These findings highlight YY1AP1’s potential as both a therapeutic target and a tool for risk stratification.
Citation	Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; In press

Received	2025-11-18 09:20
Peer-Review Started	2025-11-18 09:21
First Decision by Editorial Office Director	2025-12-04 09:08
Return for Revision	2025-12-04 09:08
Revised	2025-12-17 09:56
Publication Fee Transferred	2025-12-25 03:57
Second Decision by Editor	2026-02-10 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 06:47
Articles in Press	2026-02-10 06:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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