Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116561
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical and endoscopic characteristics of early gastric signet ring cell carcinoma based on Helicobacter pylori infection status
Manuscript Source	Unsolicited Manuscript
All Author List	Quan Lu, Feng Xiong, Hui-Cheng Gu, Quan-Zhou Peng, Jun Yao, De-Feng Li, Bo-Wen Huang and Li-Sheng Wang
Funding Agency and Grant Number	Funding Agency Grant Number Sanming Project of Medicine in Shenzhen SZSM202211029 Medical Scientific Research Foundation of Guangdong Province B2025059
Corresponding Author	Li-Sheng Wang, Chief Physician, MD, Professor, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), No. 1017 Dongmen North Road, Luohu District, Shenzhen 518020, Guangdong Province, China. wangls168@163.com
Key Words	Early gastric cancer; Gastric signet ring cell carcinoma; Helicobacter pylori; Endoscopic submucosal dissection; Endoscopic characteristics
Core Tip	This study elucidates the different clinical and endoscopic features of early gastric signet ring cell carcinoma (eGSRCC) based on Helicobacter pylori (H. pylori) status. H. pylori-uninfected lesions were typically flat and pale in the lower gastric body, while H. pylori-positive lesions were often depressed and reddish. All delayed post-endoscopic submucosal dissection (ESD) bleeding events occurred in H. pylori-positive patients. Recognizing these patterns can aid in early detection. More importantly, H. pylori eradication prior to ESD should be considered to optimize endoscopic visualization and may reduce procedural bleeding risk, thereby refining the therapeutic approach for eGSRCC.
Citation	Lu Q, Xiong F, Gu HC, Peng QZ, Yao J, Li DF, Huang BW, Wang LS. Clinical and endoscopic characteristics of early gastric signet ring cell carcinoma based on Helicobacter pylori infection status. World J Gastrointest Oncol 2026; In press

Received	2025-11-19 12:53
Peer-Review Started	2025-11-19 12:54
First Decision by Editorial Office Director	2025-12-09 10:01
Return for Revision	2025-12-10 12:58
Revised	2025-12-22 16:14
Publication Fee Transferred	2025-12-23 14:22
Second Decision by Editor	2026-01-15 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-15 05:36
Articles in Press	2026-01-15 05:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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