Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116567
Country	Egypt

Category	Oncology
Manuscript Type	Observational Study
Article Title	Dual-parameter liquid biopsy using plasma miR-21-5p and T-cell LAIR-1 MFI for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort
Manuscript Source	Invited Manuscript
All Author List	Dalia E Sherief, Hadeer Hamdy Shehata, Nahla Nosair, Amira AA Othman, Emad Sadaka and Rasha Elgamal
Funding Agency and Grant Number
Corresponding Author	Amira AA Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Hepatocellular carcinoma; microRNAs; hsa-miR-21-5p; hsa-miR-155-5p; Leukocyte-associated immunoglobulin-like receptor-1; Biomarkers; Receiver operating characteristic curve; Egypt
Core Tip	Early, accurate, and non-invasive diagnosis of hepatocellular carcinoma (HCC) remains a major clinical challenge, particularly in Egypt, where hepatitis C virus-related cirrhosis is prevalent. This study introduces a novel dual-parameter liquid biopsy combining plasma miR-21-5p (a tumor-derived oncomiR) and T-cell leukocyte-associated immunoglobulin-like receptor-1 MFI (an immune-checkpoint marker). In a prospective Egyptian cohort, this approach achieved exceptional diagnostic accuracy (area under the curve > 0.99) and maintained high sensitivity in early-stage and α-fetoprotein-negative HCC. The findings propose an integrated molecular-immune diagnostic pathway that could substantially improve HCC surveillance and early detection in high-risk populations.
Citation	Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T-cell LAIR-1 MFI for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2025; In press

Received	2025-11-14 07:59
Peer-Review Started	2025-11-14 07:59
First Decision by Editorial Office Director	2025-11-19 09:38
Return for Revision	2025-11-19 09:38
Revised	2025-11-20 00:57
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 06:57
Articles in Press	2025-12-24 06:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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