Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116568
Country	Brazil

Category	Immunology
Manuscript Type	Basic Study
Article Title	Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities
Manuscript Source	Invited Manuscript
All Author List	Paola B Da Silva, Laís Lopes-Bute, Janaína Fischer, Ana P Parcianello, Renata Pires-Duarte, Rafael M Luiz, Ana P C Brandalize, Fabrício F Melo, Cinthia F Wendel, Kádima N Teixeira and Ana C Zarpelon-Schutz
Funding Agency and Grant Number
Corresponding Author	Ana C Zarpelon-Schutz, PhD, Pós-graduação em Bioquímica Biologia Molecular, Universidade Federal do Paraná - Setor Palotina, Max Planck, 3796, Palotina 85950-000, Paraná, Brazil. ana.zarpelon@ufpr.br
Key Words	Antinociceptive activity; Anti-inflammatory activity; Butia capitata; Colorectal cancer; Cyclooxygenase-2; Phenolic compounds; Ulcerative colitis
Core Tip	The hydroalcoholic extract of Butia capitata showed antinociceptive activity in mice, in models of pain and/or hyperalgesia caused by acetic acid, formalin, and carrageenan, with an emphasis on reducing the histological damage and the pain symptoms caused by acetic acid-induced acute colitis. The in silico results indicate the potential of phenolic compounds of the extract to inhibit cellular pathways and receptors involved in inflammatory processes, as well as reduce the activation of pathways that promote genetic damage and tumorigenesis.
Citation	Da Silva PB, Lopes-Bute L, Fischer J, Parcianello AP, Pires-Duarte R, Luiz RM, Brandalize APC, Melo FF, Wendel CF, Teixeira KN, Zarpelon-Schutz AC. Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities.

Received	2025-11-17 04:35
Peer-Review Started	2025-11-17 04:35
First Decision by Editorial Office Director	2025-11-28 07:08
Return for Revision	2025-11-28 07:08
Revised	2025-12-12 23:07
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 11:46
Articles in Press	2026-02-06 11:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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