Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	116578
Country	China

Category	Pediatrics
Manuscript Type	Retrospective Study
Article Title	Analysis of gut microbiota and serum I-FABP and PRDX1 levels in children with enterocolitis after congenital megacolon surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Hua-Lin Sun, Yu-Tong Cui, Bing-Li Huo, Xiao-Cui Zheng and Wei-Li Kang
Funding Agency and Grant Number
Corresponding Author	Wei-Li Kang, Pediatric Department, Hengshui People's Hospital, No. 180, Renmin East Road, Hengshui 053099, Hebei Province, China. kangweili666@163.com
Key Words	Hirschsprung’s disease; Hirschsprung-associated enterocolitis; Gut microbiota; Intestinal fatty acid-binding protein; Peroxiredoxin 1
Core Tip	This retrospective study examined the characteristics of, and correlations between, preoperative gut microbiota and serum intestinal fatty acid-binding protein (I-FABP) and peroxiredoxin 1 (PRDX1) levels in children who developed Hirschsprung-associated enterocolitis (HAEC) after Hirschsprung’s disease (HD) surgery, with the aim of informing risk assessment and preventive intervention strategies. Preliminary analyses indicated that children with postoperative HAEC exhibited decreased abundance of beneficial bacteria, increased abundances of pathogenic bacteria and elevated preoperative levels of C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), I-FABP and PRDX1. Preoperative levels of CRP, TNF-α, IL-6, IL-8, I-FABP and PRDX1 were significantly correlated with gut microbiota abundance, and the risk of HAEC after HD was strongly associated with preoperative gut microbiota structure and with I-FABP and PRDX1 levels.
Citation	Sun HL, Cui YT, Huo BL, Zheng XC, Kang WL. Analysis of gut microbiota and serum I-FABP and PRDX1 levels in children with enterocolitis after congenital megacolon surgery. World J Gastrointest Surg 2026; In press

Received	2025-11-28 09:52
Peer-Review Started	2025-11-28 09:52
First Decision by Editorial Office Director	2025-12-18 09:00
Return for Revision	2025-12-18 09:00
Revised	2025-12-30 15:45
Publication Fee Transferred	2026-01-06 09:02
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 04:01
Articles in Press	2026-02-09 04:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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