Publication Name	World Journal of Psychiatry
Manuscript ID	116579
Country	China

Category	Psychology
Manuscript Type	Retrospective Study
Article Title	Efficacy and influencing factors of 3-N-Butylphthalide-trazodone combination in managing post-ischemic stroke depression
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Hua Zhu, Yong-Sen Lin and Zhu-Quan Hong
Funding Agency and Grant Number
Corresponding Author	Zhu-Quan Hong, Associate Chief Physician, Department of Neurology, Quanzhou First Hospital, No. 1028 Anji South Road, Fengze District, Quanzhou 362000, Fujian Province, China. 971696252@qq.com
Key Words	3-N-Butylphthalide; Trazodone; Post-ischemic stroke depression; Therapeutic effectiveness; Influencing factors
Core Tip	For the optimization of treatment for post-ischemic stroke depression, this study verified the efficacy of the 3-N-Butylphthalide (NBP)-Trazodone (TRZ) combination and explored efficacy-associated determinants. Without increasing the total incidence of adverse reactions, the NBP-TRZ combination was significantly superior to TRZ monotherapy in therapeutic efficacy, while also significantly improving patients’ neurological function and daily living ability, alleviating depression, and regulating serum neurotransmitters. Comorbid hyperlipidemia, low 5-hydroxytryptamine, reduced dopamine, and TRZ monotherapy were associated with treatment ineffectiveness in such patients.
Citation	Zhu ZH, Lin YS, Hong ZQ. Efficacy and influencing factors of 3-N-Butylphthalide-trazodone combination in managing post-ischemic stroke depression. World J Psychiatry 2026; In press

Received	2026-01-30 09:41
Peer-Review Started	2026-01-30 09:42
First Decision by Editorial Office Director	2026-02-26 06:18
Return for Revision	2026-02-26 06:18
Revised	2026-03-12 16:23
Publication Fee Transferred	2026-03-31 06:14
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 10:16
Articles in Press	2026-05-08 10:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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