Publication Name	World Journal of Experimental Medicine
Manuscript ID	116584
Country	Japan

Category	Allergy
Manuscript Type	Clinical Trials Study
Article Title	Effects of olopatadine hydrochloride on substance P concentrations in nasal secretions and nasal symptoms
Manuscript Source	Invited Manuscript
All Author List	Fumihiko Katagiri, Saori Hatoyama-Tanaka, Tetsuo Watanabe, Risa Takayanagi, Masashi Suzuki and Yasuhiko Yamada
Funding Agency and Grant Number
Corresponding Author	Fumihiko Katagiri, Lecturer, PhD, Department of Clinical Evaluation of Drug Efficacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Tōkyō, Japan. katagiri@toyaku.ac.jp
Key Words	Allergic rhinitis; Cedar pollinosis; Histamine H1 receptor antagonist; Nasal blockage; Nasal secretions; Olopatadine hydrochloride; Rhinorrhea; Sneezing; Substance P; Symptoms
Core Tip	Olopatadine hydrochloride (olopatadine), a histamine H1 receptor antagonist, is used to treat various allergic diseases. It has been reported that the concentration of substance P (SP) in the nasal secretions of patients with pollinosis is higher than that of healthy individuals. Furthermore, it has been reported that olopatadine inhibits release of SP. In this study, we found that olopatadine reduces the concentration of SP in the nasal secretions of patients with pollinosis, suggesting that olopatadine reduces SP concentrations and may therefore contribute to improvement in symptoms.
Citation	Katagiri F, Tanaka SH, Watanabe T, Takayanagi R, Suzuki M, Yamada Y. Effects of olopatadine hydrochloride on substance P concentrations in nasal secretions and nasal symptoms. World J Exp Med 2026; In press

Received	2025-11-17 04:24
Peer-Review Started	2025-11-17 04:24
First Decision by Editorial Office Director	2026-01-07 02:13
Return for Revision	2026-01-07 02:13
Revised	2026-01-20 06:19
Publication Fee Transferred
Second Decision by Editor	2026-02-24 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-24 10:01
Articles in Press	2026-02-24 10:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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