Publication Name	World Journal of Gastroenterology
Manuscript ID	116590
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Niu Huang mitigates dextran sulfate sodium-induced colitis by modulating farnesoid X receptor activation and the component 3/NLRP3 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Juan Shi, Chong-Yang Ma, Xiao-Hui Zhang, Kun-Jing Liu, Jin-Ying Liu, Qing-Guo Wang, Xue-Qian Wang, Fa-Feng Cheng and Tian Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82374165, No. 82405050, and No. 82004327 Fundamental Research Funds for the Central Universities, China No. 3332024017 Research Project of Hebei Provincial Administration of Traditional Chinese Medicine No. 2025086
Corresponding Author	Tian Xu, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. xutian@pumch.cn
Key Words	Niu Huang; Ulcerative colitis; Network pharmacology; Farnesoid X receptor; Complement component 3/NOD-like receptor family pyrin domain containing 3 signaling pathway; Inflammation
Core Tip	This study demonstrates that Niu Huang effectively alleviates ulcerative colitis. By identifying its active components and employing transcriptomic and proteomic sequencing to predict mechanisms, this study reveals that this drug exerts anti-colitis effects by activating the farnesoid X receptor (FXR), which subsequently inhibits nuclear factor kappa B transcription. This inhibition reduces the accumulation of complement component 3 and suppresses excessive activation of the NOD-like receptor family pyrin domain containing 3 inflammasome in colon tissue, alleviating intestinal inflammation. The critical role of FXR was conclusively validated using both FXR antagonist guggulsterone and Fxr-knockout mouse models.
Citation	Shi J, Ma CY, Zhang XH, Liu KJ, Liu JY, Wang QG, Wang XQ, Cheng FF, Xu T. Niu Huang mitigates dextran sulfate sodium-induced colitis by modulating farnesoid X receptor activation and the component 3/NLRP3 signaling pathway. World J Gastroenterol 2026; In press

Received	2025-11-18 03:48
Peer-Review Started	2025-11-18 03:48
First Decision by Editorial Office Director	2025-12-04 09:26
Return for Revision	2025-12-04 09:26
Revised	2026-01-07 15:11
Publication Fee Transferred	2026-01-09 06:49
Second Decision by Editor	2026-02-12 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 06:28
Articles in Press	2026-02-12 06:28
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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