Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	116608
Country	United Kingdom

Category	Medicine, General & Internal
Manuscript Type	Review
Article Title	Current approaches to disease severity and therapy effectiveness assessment in patients with inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Alexandre Loktionov
Funding Agency and Grant Number
Corresponding Author	Alexandre Loktionov, Director, MD, PhD, -, DiagNodus Ltd, St John’s Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. alex.loktionov@diagnodus.com
Key Words	Ulcerative colitis; Crohn’s disease; Endoscopy; Cross-section imaging; Biomarkers; Gut microbiome; Precision medicine; Multi-omics; Artificial intelligence
Core Tip	Inflammatory bowel disease patients need continuous lifetime monitoring of disease activity and effects of therapeutic interventions. This review considers a wide range of approaches currently applied for this purpose. The reviewed modalities comprise clinical criteria, endoscopy, cross-sectional imaging, detection of biomarkers in body fluids and feces, gut microbiome analysis, and application of modern technologies, such as multi-omics and artificial intelligence. Artificial intelligence-driven integration of abundant information provided by a range of diagnostic and analytical approaches outlined in this review may help in transforming the current ‘one-size-fits-all’ inflammatory bowel disease treatment concept into a truly personalized model of disease care.
Citation	Loktionov A. Current approaches to disease severity and therapy effectiveness assessment in patients with inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2026; In press

Received	2025-11-17 03:49
Peer-Review Started	2025-11-17 03:50
First Decision by Editorial Office Director	2025-11-25 09:23
Return for Revision	2025-11-25 09:23
Revised	2025-12-04 11:37
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 06:50
Articles in Press	2026-02-09 06:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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