Publication Name	World Journal of Stem Cells
Manuscript ID	116611
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia-reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy
Manuscript Source	Unsolicited Manuscript
All Author List	Wen Wen, Chen-Xi Liu, Yong Wang, Xiao-Jiong Lu, Chao Yang, Shuang-Jing Chen, Zhi-Tao Jin, Ming-Yue Qu, Jing-Yu Deng and Zheng Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Natural Science Foundation 7222229
Corresponding Author	Zheng Zhang, Associate Chief Physician, MD, Department of Cardiology, The PLA Rocket Force Characteristic Medical Center, No. 16 Xinjiekouwai Dajie, Xicheng District, Beijing 100088, China. faithword@163.com
Key Words	Ischemia-reperfusion injury; Hypoxia preconditionin; Bone marrow mesenchymal stem cells; Exosomes; Mitophagy
Core Tip	This study identifies hypoxia-preconditioned mesenchymal stem cell-derived exosomes as a potent therapeutic strategy for myocardial ischemia/reperfusion injury. High-throughput sequencing reveals miR-29b-3p as a key protective cargo that restores mitochondrial homeostasis by activating PINK1/Parkin-dependent mitophagy. miR-29b-3p significantly reduces oxidative stress, preserves mitochondrial integrity, and improves cardiac function in vivo, highlighting a promising exosome-based and mitochondria-targeted approach for future cardioprotection.
Citation	Wen W, Liu CX, Wang Y, Lu XJ, Yang C, Chen SJ, Jin ZT, Qu MY, Deng JY, Zhang Z. Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia-reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy. World J Stem Cells 2026; In press

Received	2025-11-18 05:18
Peer-Review Started	2025-11-18 05:18
First Decision by Editorial Office Director	2025-12-31 07:56
Return for Revision	2025-12-31 07:56
Revised	2026-01-12 13:15
Publication Fee Transferred	2026-01-15 08:37
Second Decision by Editor	2026-02-14 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-24 08:52
Articles in Press	2026-02-24 08:52
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Typeset the Manuscript

ISSN	1948-0210 (online)
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