Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	116625
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Ultrasound-guided-guided liver biopsy: Are we ready for routine use?
Manuscript Source	Invited Manuscript
All Author List	Filippo Antonini, Andrea Anderloni, Carlo Fabbri, Ilaria Tarantino and Antonio Facciorusso
Funding Agency and Grant Number
Corresponding Author	Filippo Antonini, Department of Gastroenterology and Interventional Endoscopy Unit, C. e G. Mazzoni Hospital, Via degli Iris 1, Ascoli Piceno 63100, Marche, Italy. filippore@yahoo.it
Key Words	Endoscopic ultrasound-guided liver biopsy; Percutaneous liver biopsy; Endoscopic ultrasound-guided-fine-needle biopsy; Diagnostic yield; Parenchymal liver disease
Core Tip	Endoscopic ultrasound-guided liver biopsy (EUS-LB) has emerged as a feasible and safe alternative to percutaneous liver biopsy for evaluating parenchymal liver disease. However, comparative evidence shows equivalent diagnostic adequacy and safety between the two techniques, with percutaneous liver biopsy yielding lower procedural costs. EUS-LB remains more invasive and resource-intensive, requiring endoscopic expertise and sedation. While EUS-LB is valuable when combined with other endoscopic interventions or when percutaneous access is not feasible, current data do not justify its routine use. Future studies should focus on cost-effectiveness, standardization, and patient-centered outcomes before broader adoption.
Citation	Antonini F, Anderloni A, Fabbri C, Tarantino I, Facciorusso A. Ultrasound-guided-guided liver biopsy: Are we ready for routine use? World J Gastrointest Endosc 2026; In press

Received	2025-11-18 06:56
Peer-Review Started	2025-11-18 06:56
First Decision by Editorial Office Director	2025-12-16 09:11
Return for Revision	2025-12-16 09:11
Revised	2025-12-20 20:59
Publication Fee Transferred
Second Decision by Editor	2026-01-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-13 07:27
Articles in Press	2026-01-13 07:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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