Publication Name	World Journal of Hepatology
Manuscript ID	116657
Country	Italy

Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Treatment of chronic hepatitis B infection in infants and young children: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Simona Carrera, Chiara Rubino, Elisa Bartolini and Giuseppe Indolfi
Funding Agency and Grant Number
Corresponding Author	Simona Carrera, MD, Pediatric and Liver Unit, Meyer Children's Hospital IRCCS, Viale Gaetano Pieraccini 24, Florence 50139, Tuscany, Italy. simona.carrera@meyer.it
Key Words	Chronic hepatitis B virus infection; Children; Functional cure; Hepatitis B surface antigen loss; Antiviral treatment
Core Tip	Chronic hepatitis B is a major global health issue, largely driven by mother-to-child transmission. Spontaneous hepatitis B surface antigen seroclearance occurs at about 1% per year. Emerging evidence suggests that starting antiviral therapy at a young age might lead to higher functional cure rates. This review examines evidence and implications of early treatment.
Citation	Carrera S, Rubino C, Bartolini E, Indolfi G. Treatment of chronic hepatitis B infection in infants and young children: A systematic review. World J Hepatol 2026; In press

Received	2025-11-19 07:42
Peer-Review Started	2025-11-19 07:42
First Decision by Editorial Office Director	2025-12-24 10:13
Return for Revision	2025-12-24 10:13
Revised	2026-01-07 18:29
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 05:50
Articles in Press	2026-02-03 05:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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