Publication Name	World Journal of Clinical Oncology
Manuscript ID	116662
Country	United Arab Emirates

Category	Medical Laboratory Technology
Manuscript Type	Basic Study
Article Title	Overexpression of low-molecular-weight caldesmon is associated with aggressive phenotypes and epithelial-mesenchymal transition in breast cancer cells
Manuscript Source	Unsolicited Manuscript
All Author List	Alya AlNuaimi, Vidhya A Nair, Noura Al-Khayyal, Ashna Suliman, Lara J Bou Malhab, Rifat Hamoudi, Mohamad Hamad, Iman M Talaat and Wael M Abdel-Rahman
Funding Agency and Grant Number
Corresponding Author	Wael M Abdel-Rahman, MD, PhD, Professor, Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, University City, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae
Key Words	Low-molecular-weight caldesmon; Breast cancer; Triple-negative; Epithelial-mesenchymal transition; Invasion; Metastasis
Core Tip	Low-molecular-weight caldesmon (l-CAD) plays a key role in triple-negative breast cancer (TNBC) progression by promoting epithelial-mesenchymal transition and enhancing cell motility and invasiveness. This study identifies CALD1 transcript variant 2 as the key isoform driving tumorigenesis in TNBC. Immunohistochemical analysis confirmed l-CAD expression in the cytoplasm and stroma of cancer cells and stromal cells, with significant associations with lymphovascular invasion and receptor status. High CALD1 levels in TNBC are associated with poor prognosis and reduced disease-free survival, highlighting l-CAD as a potential driver of metastasis and a promising prognostic biomarker.
Citation	AlNuaimi A, Nair VA, Al-khayyal N, Suliman A, Malhab LB, Hamoudi R, Hamad M, Talaat IM, Abdel-Rahman WM. Overexpression of low-molecular-weight caldesmon is associated with aggressive phenotypes and epithelial-mesenchymal transition in breast cancer cells. World J Clin Oncol 2026; In press

Received	2025-11-18 10:18
Peer-Review Started	2025-11-18 10:19
First Decision by Editorial Office Director	2025-12-18 09:34
Return for Revision	2025-12-18 09:34
Revised	2026-01-27 21:10
Publication Fee Transferred
Second Decision by Editor	2026-03-02 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-02 07:37
Articles in Press	2026-03-02 07:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2026-04-29 08:11

ISSN	2218-4333 (online)
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