Publication Name	World Journal of Hepatology
Manuscript ID	116689
Country	Russia

Category	Immunology
Manuscript Type	Minireviews
Article Title	Monocyte reprogramming and trained immunity: Linking metabolism to inflammation in non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Stanislav Kotlyarov
Funding Agency and Grant Number	Funding Agency Grant Number Russian Scientific Foundation No. 25-25-01166
Corresponding Author	Stanislav Kotlyarov, PhD, Department of Nurse, Ryazan State Medical University, Russian Federation, Ryazan, Vysokovoltnaya, 9, Ryazan 390005, Russia. skmr1@yandex.ru
Key Words	Non-alcoholic fatty liver disease; Innate immune system; Immunometabolism; Metabolic reprogramming; Priming; Trained immunity; Monocytes
Core Tip	Non-alcoholic fatty liver disease is a systemic immunometabolic disorder. Chronic exposure to metabolic factors such as lipotoxicity and hyperglycemia induces long-term functional reprogramming of innate immunity, underlying phenomena like priming and trained immunity. The resulting hyperactive pro-inflammatory phenotype of monocytes and macrophages serves as a key mechanism linking obesity, insulin resistance, and chronic liver inflammation, opening new avenues for therapeutic intervention.
Citation	Kotlyarov S. Monocyte reprogramming and trained immunity: Linking metabolism to inflammation in non-alcoholic fatty liver disease. World J Hepatol 2026; In press

Received	2025-11-18 07:03
Peer-Review Started	2025-11-18 09:04
First Decision by Editorial Office Director	2025-12-03 10:03
Return for Revision	2025-12-03 10:03
Revised	2025-12-09 12:03
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 07:36
Articles in Press	2026-02-05 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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