Publication Name	World Journal of Cardiology
Manuscript ID	116754
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Letter to the Editor
Article Title	Rethinking pharmacologic strategies in heart failure with preserved ejection fraction: Insights from beta-blocker vs calcium channel blocker comparisons
Manuscript Source	Invited Manuscript
All Author List	Jia-Jin Li, Jie Tian and Yu-Xing Yuan
Funding Agency and Grant Number
Corresponding Author	Yu-Xing Yuan, PhD, Postdoc, Department of Cardiology, Children’s Hospital of Chongqing Medical University, No. 136 Zhongshan Er Road, Yu Zhong District, Chongqing 400014, China. yuanyuxing@stu.cqmu.edu.cn
Key Words	Heart failure with preserved ejection fraction; Beta-blocker; Calcium channel blocker; Pharmacotherapy; Precision medicine; Phenotypi
Core Tip	Using simulated data from electronic health records of patients with heart failure with preserved ejection fraction (HFpEF), Mansoor et al found that beta-blockers were associated with lower mortality and fewer heart failure hospitalizations than calcium channel blockers, albeit with more bradycardia and discontinuation. We view this not as a simple “winner-versus-loser” result, but as a signal of underlying HFpEF phenotypes and evolving therapy. Our letter outlines how beta-blockers and calcium channel blockers might be integrated with sodium-glucose cotransporter 2 inhibitors, ARNI, and metabolic agents in phenotype-guided HFpEF care.
Citation	Li JJ, Tian J, Yuan YX. Rethinking pharmacologic strategies in heart failure with preserved ejection fraction: Insights from beta-blocker vs calcium channel blocker comparisons. World J Cardiol 2026; In press

Received	2025-11-27 01:01
Peer-Review Started	2025-11-27 01:01
First Decision by Editorial Office Director	2025-12-03 10:14
Return for Revision	2025-12-03 10:14
Revised	2025-12-04 09:16
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 07:45
Articles in Press	2026-01-09 07:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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