Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116764
Country	China

Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study
Manuscript Source	Unsolicited Manuscript
All Author List	Han Wang, Zhen-Ying Cao, Chun-Yan Xia, Xia Sheng, Yun Zhao, Hong-Zhen Chen, Wen-Ming Cong, Miao-Xia He and Hui Dong
Funding Agency and Grant Number	Funding Agency Grant Number Noncommunicable Chronic Diseases-National Science and Technology Major Project No. 2023ZD0500100 Shanghai Leading Talent Program of Eastern Talent Plan No. BJWS2024084 Municipal Hospital Clinical Technology Promotion and Management Optimization Project by Shanghai Shenkang Hospital Development Center No. SHDC22023208 Shanghai Science and Technology Innovation Action Plan-Medical Innovation Research Project No. 22Y11909100 Naval Medical University Basic Medical Research Project No. 2023NQ095 Take-off Project Talent Program of EHBH No. TF2024XSJJ02
Corresponding Author	Hui Dong, Associate Faculty, Associate Professor, PhD, Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. huidongwh@126.com
Key Words	Combined hepatocellular-cholangiocarcinoma; Mixed hepatocellular-cholangiocarcinoma; Hepatic steatosis; Hepatocellular steatosis; Liver steatosis; Fatty liver disease; Pathological assessment; Alcohol-related liver disease; Metabolic dysfunction-associated steatotic liver disease
Core Tip	This retrospective multicenter study investigated the prognostic influence of hepatic steatosis in patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA). Severe hepatic steatosis was associated with a favorable prognosis in cHCC-CCA patients. This protective effect was particularly significant in preventing early recurrence and was more pronounced among non-cirrhotic patients. We propose that the evaluation of hepatic steatosis be incorporated into the routine pathological diagnosis of cHCC-CCA to optimize postoperative management for this tumor entity.
Citation	Wang H, Cao ZY, Xia CY, Sheng X, Zhao Y, Chen HZ, Cong WM, He MX, Dong H. Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study. World J Gastrointest Oncol 2026; In press

Received	2025-11-20 08:52
Peer-Review Started	2025-11-20 09:08
First Decision by Editorial Office Director	2025-12-11 08:21
Return for Revision	2025-12-11 08:21
Revised	2025-12-18 13:36
Publication Fee Transferred	2025-12-22 07:37
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 07:22
Articles in Press	2026-02-05 07:22
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ISSN	1948-5204 (online)
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