Publication Name	World Journal of Gastroenterology
Manuscript ID	116779
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Decoding pediatric-adult divergence in inflammatory bowel disease via multi-omics integration
Manuscript Source	Unsolicited Manuscript
All Author List	Peng Zhang and Shang-Ming Liu
Funding Agency and Grant Number
Corresponding Author	Peng Zhang, Associate Professor, PhD, Postdoctoral Fellow, Medical Basic Experiment Teaching Center, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Lixia District, Jinan 250012, Shandong Province, China. zhangpeng1990@sdu.edu.cn
Key Words	Inflammatory bowel disease; Metabolomics; Metagenomics; Pediatric patients; Microbial profiling; Single-cell multi-omics
Core Tip	This multi-omics investigation delineates distinct age-specific microbial and metabolic signatures differentiating pediatric and adult inflammatory bowel disease, identifying biomarkers for early diagnosis and risk stratification. While demonstrating promising potential for refining inflammatory bowel disease diagnostics, these findings require further validation and mechanistic exploration to facilitate clinical translation. The integration of metabolomic and metagenomic methodologies provides a robust framework for elucidating pathophysiological divergence across age groups, providing a foundation for personalized management strategies.
Citation	Zhang P, Liu SM. Decoding pediatric-adult divergence in inflammatory bowel disease via multi-omics integration. World J Gastroenterol 2026; In press

Received	2025-11-24 07:32
Peer-Review Started	2025-11-24 07:44
First Decision by Editorial Office Director	2025-12-05 09:36
Return for Revision	2025-12-05 09:36
Revised	2025-12-14 02:14
Publication Fee Transferred
Second Decision by Editor	2026-01-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-13 04:19
Articles in Press	2026-01-13 04:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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