Publication Name	World Journal of Gastroenterology
Manuscript ID	116781
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort
Manuscript Source	Unsolicited Manuscript
All Author List	Xian-Zong Ma, Xing-Zhao Han, Wen-Yu Zhang, Feng Tian, Xu-Chun Zhou, Lin-Yan Zhou, Yong-Sheng Teng, Ling Lei, Jian-Qiu Sheng, Peng Jin, Xin-Mei Zhao and Yan Jia
Funding Agency and Grant Number	Funding Agency Grant Number the Capital Health Development Scientific Research Project 2018-1-5091 National Natural Science Foundation of China 82500685
Corresponding Author	Yan Jia, Professor, Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, No.5 Nanmencang, Dongcheng District, Beijing 100700, China. jiayan328@163.com
Key Words	Crohn's disease; Ustekinumab; Postoperative recurrence; Rutgeerts score; Endoscopic improvement
Core Tip	This multicenter study demonstrated that ustekinumab (UST) effectively addressed the management of postoperative recurrence in patients with Crohn's disease in China. Results showed high rates of endoscopic (81.7%) and clinical remission (91.5%) at 24 weeks. A multivariate analysis identified first-line UST use and shorter disease duration as independent predictors of superior outcomes. The favorable safety profile supports UST as a potent therapeutic option, particularly when initiated early as a first-line biologic strategy for postoperative management.
Citation	Ma XZ, Han XZ, Zhang WY, Tian F, Zhou XC, Zhou LY, Teng YS, Lei L, Sheng JQ, Jin P, Zhao XM, Jia Y. Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort. World J Gastroenterol 2026; In press

Received	2025-11-26 03:02
Peer-Review Started	2025-11-26 03:02
First Decision by Editorial Office Director	2025-12-17 10:08
Return for Revision	2025-12-17 10:08
Revised	2025-12-31 11:42
Publication Fee Transferred	2026-01-04 05:30
Second Decision by Editor	2026-01-28 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-28 07:30
Articles in Press	2026-01-28 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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