Publication Name	World Journal of Gastroenterology
Manuscript ID	116783
Country	Italy

Category	Pathology
Manuscript Type	Case Report
Article Title	Abdominal nodular histiocytic/mesothelial hyperplasia - intraoperative pitfalls, differential diagnosis, literature review: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Piergiuseppe Colombo, Giulia Dani, Benedetta Saracini, Carlo Castoro and Paola Spaggiari
Funding Agency and Grant Number
Corresponding Author	Piergiuseppe Colombo, Associate Professor, Department of Biomedical Science, Humanitas University, Via Rita Levi Montalcini, 4, Pieve Emanuele, Milan 20072, Italy. piergiuseppe.colombo@hunimed.eu
Key Words	Nodular histiocytic hyperplasia; Mesothelial hyperplasia; Nodular histiocytic/mesothelial hyperplasia; Peritoneum; Frozen section; Mesothelial cells; Pitfall; Carcinomatosis; Gastric adenocarcinoma; Case report
Core Tip	Nodular histiocytic/mesothelial hyperplasia is a rare benign lesion that may mimic peritoneal dissemination of malignancy, especially during frozen-section examination. This case emphasizes the diagnostic pitfalls arising from its histologic resemblance to metastatic carcinoma and highlights how coexistence with true metastatic implants increases the risk of misinterpretation. Few reports describe concurrent metastatic carcinoma and nodular histiocytic/mesothelial hyperplasia, making intraoperative differentiation particularly challenging. Knowledge of its characteristic morphology and immunoprofile is crucial for surgeons and pathologists.
Citation	Colombo P, Dani G, Saracini B, Castoro C, Spaggiari P. Abdominal nodular histiocytic/mesothelial hyperplasia - intraoperative pitfalls, differential diagnosis, literature review: A case report. World J Gastroenterol 2026; In press

Received	2025-11-21 05:20
Peer-Review Started	2025-11-21 05:21
First Decision by Editorial Office Director	2026-01-07 09:20
Return for Revision	2026-01-07 09:20
Revised	2026-01-09 14:34
Publication Fee Transferred	2026-02-03 18:19
Second Decision by Editor	2026-03-26 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 08:34
Articles in Press	2026-03-26 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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