Publication Name	World Journal of Gastroenterology
Manuscript ID	116790
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Vitamin D and inflammatory bowel diseases
Manuscript Source	Unsolicited Manuscript
All Author List	Ioannis Bontsiou, Georgios Tzikos, Angeliki Chorti, Angeliki Vouchara, Alexandra Menni, Maria Papaioannou, Katerina Kotzampassi and Theodosios S Papavramidis
Funding Agency and Grant Number
Corresponding Author	Ioannis Bontsiou, MD, Department of Surgery, Aristotle University of Thessaloniki, Street Kiriakidi 1, Thessaloniki 54636, Greece. ibontsiou@ahepahosp.gr
Key Words	Vitamin D; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Pathogenesis; Review; Immune modulation; Vitamin D receptor signaling; Disease activity; Vitamin D supplementation
Core Tip	Vitamin D (VD) is a main regulator of immune-mediated diseases, including inflammatory bowel disease. The VD-VD receptor signaling pathway plays a pivotal role in maintaining the integrity of the intestinal epithelial barrier and gastrointestinal microbiota. Lower VD levels seem to play a part to the pathogenesis of inflammatory bowel disease and reflect the disease activity. VD deficiency is linked to a higher risk of colorectal cancer. In contrast, increased VD levels are associated with reduced bowel resection risk and fewer hospitalizations. Finally, there is promising evidence that VD administration could act as a therapeutic factor.
Citation	Bontsiou I, Tzikos G, Chorti A, Vouchara A, Menni A, Papaioannou M, Kotzampassi K, Papavramidis TS. Vitamin D and inflammatory bowel diseases. World J Gastroenterol 2026; In press

Received	2025-11-27 02:24
Peer-Review Started	2025-11-27 07:35
First Decision by Editorial Office Director	2026-01-12 09:17
Return for Revision	2026-01-12 09:17
Revised	2026-02-08 18:19
Publication Fee Transferred	2026-02-13 17:35
Second Decision by Editor	2026-03-26 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 06:42
Articles in Press	2026-03-26 06:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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