Publication Name	World Journal of Virology
Manuscript ID	116792
Country	China

Category	Virology
Manuscript Type	Review
Article Title	Antiviral innate immunity and adaptive immune responses against monkeypox and viral immune evasion
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Hao Liang, Ping Huang, Jian-Jun Shen, Jie Wei, Wen-Xian Qian and Chang-Hua Yi
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Topics of Jiangsu Provincial Healthcare Commission No. M2021078 Nanjing Medical Key Science and Technology Development Project No. ZKX20032 the National Natural Science Foundation of China No. 92169106
Corresponding Author	Chang-Hua Yi, Department of Clinical Research Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Zhongfu Road 2, Nanjing 210003, Jiangsu Province, China. chhuayi@sina.cn
Key Words	Immune evasion; Adaptive immune; Innate immune; Monkeypox virus; Poxviridae family
Core Tip	The monkeypox virus has emerged as a global public health concern since 2022. It provides a comprehensive update on the host’s antiviral innate and adaptive immune responses against monkeypox virus and related orthopox viruses. The article further explores the complex mechanisms of viral immune evasion, including strategies such as APOBEC3-driven mutations that may influence viral evolution and immune recognition. Understanding these intricate host-pathogen interactions is critical for developing novel treatments and next-generation vaccines.
Citation	Liang ZH, Huang P, Shen JJ, Wei J, Qian WX, Yi CH. Antiviral innate immunity and adaptive immune responses against monkeypox and viral immune evasion. World J Virol 2026; In press

Received	2025-11-28 01:31
Peer-Review Started	2025-11-28 01:32
First Decision by Editorial Office Director	2025-12-02 08:13
Return for Revision	2025-12-02 08:13
Revised	2026-03-06 07:36
Publication Fee Transferred	2026-03-10 23:59
Second Decision by Editor	2026-04-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 06:14
Articles in Press	2026-04-08 06:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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