Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116821
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Ying Zhang, Run-Ling Zhang, Yu-Yuan Jia, Yan Liu, Ling Zhu, Feng Liu and Hui-Ying Rao
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2022YFA1303804
Corresponding Author	Hui-Ying Rao, Professor, Peking University People's Hospital, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Peking University People's Hospital, Peking University Hepatology Institute, Infectious Disease and Hepatology Center of Peking University People's Hospital, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, No. 133, Fuchengmennei Street, Xicheng District, Beijing 100044, China. rao.huiying@163.com
Key Words	Chitinase-3-like protein 1; Viral hepatitis; Non-viral hepatitis; Liver cirrhosis; Hepatocellular carcinoma
Core Tip	Serum chitinase-3-like protein 1 (CHI3L1) demonstrates robust diagnostic performance for liver cirrhosis [area under the receiver operating characteristic curve (AUC) = 0.874], hepatocellular carcinoma (HCC; AUC = 0.858) and HCC recurrence (AUC = 0.723) in liver disease patient cohorts. CHI3L1 exhibits positive correlations with liver stiffness measurement and the fibrosis-4 index, effectively differentiates fibrosis grades F3 and F4, and emerged as a reliable non-invasive biomarker for liver disease stratification, treatment monitoring and prognosis prediction, with superior performance than single traditional indices.
Citation	Zhang HY, Zhang RL, Jia YY, Liu Y, Zhu L, Liu F, Rao HY. Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma. World J Gastrointest Oncol 2026; In press

Received	2025-11-21 07:48
Peer-Review Started	2025-11-21 08:03
First Decision by Editorial Office Director	2025-12-26 09:51
Return for Revision	2025-12-26 09:51
Revised	2026-01-04 11:27
Publication Fee Transferred	2026-01-06 04:16
Second Decision by Editor	2026-01-12 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 08:04
Articles in Press	2026-01-12 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com