Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	116822
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Visceral obesity exacerbates perioperative muscle loss and impairs survival in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yun Wang, Jun Bu, Chen-Yang Zhan, Da-Lin Xu, Jia-Qi Hu, Ming-Hao Zhang, Ke-Jin Zhu and Yang Qi
Funding Agency and Grant Number
Corresponding Author	Jun Bu, Chief Physician, MD, PhD, Department of General Surgery, Sichuan University Affiliated Chengdu Second People’s Hospital, No. 10 Qingyun South Street, Jinjiang District, Chengdu 610021, Sichuan Province, China. bj_227688@126.com
Key Words	Colorectal cancer; Visceral fat; Skeletal muscle loss; Sarcopenic obesity; Prognosis
Core Tip	This study identifies high visceral fat area as an independent driver of perioperative skeletal muscle loss and poor survival in colorectal cancer. Using dynamic computed tomography monitoring, we demonstrate that visceral obesity exacerbates muscle wasting through chronic inflammation. Paradoxically, higher preoperative muscle mass increased skeletal muscle loss risk, potentially indicating underlying myosteatosis. These findings redefine the fat-muscle axis in cancer prognosis and highlight the critical need for preoperative body composition assessment to guide metabolic interventions and improve long-term outcomes.
Citation	Wang Y, Bu J, Zhan CY, Xu DL, Hu JQ, Zhang MH, Zhu KJ, Qi Y. Visceral obesity exacerbates perioperative muscle loss and impairs survival in colorectal cancer. World J Gastrointest Surg 2026; In press

Received	2025-11-21 07:52
Peer-Review Started	2025-11-21 07:53
First Decision by Editorial Office Director	2025-12-11 07:56
Return for Revision	2025-12-11 07:56
Revised	2025-12-23 11:35
Publication Fee Transferred	2025-12-26 06:11
Second Decision by Editor	2026-02-10 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 03:27
Articles in Press	2026-02-10 03:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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