Publication Name	World Journal of Stem Cells
Manuscript ID	116829
Country	Brazil

Category	Cell & Tissue Engineering
Manuscript Type	Minireviews
Article Title	Phytocannabinoid-induced priming and differentiation of mesenchymal stem cells: Therapeutic potential
Manuscript Source	Invited Manuscript
All Author List	Lucas Vinícius de Oliveira Ferreira, Pedro Henrique Domingues de Oliveira and Rogério Martins Amorim
Funding Agency and Grant Number	Funding Agency Grant Number Doctoral Scholarship granted by the São Paulo Research Foundation (FAPESP) 2024/19980-0
Corresponding Author	Rogério Martins Amorim, Associate Professor, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University, Prof. Dr. Walter Maurício Corrêa Street, s/n, Botucatu 18618-681, São Paulo, Brazil. rogerio.amorim@unesp.br
Key Words	Cannabidiol; Cannabinoid receptors; Δ9-tetrahydrocannabinol; Endocannabinoid system; Immunomodulation
Core Tip	Phytocannabinoids have emerged as promising modulators of mesenchymal stem cell behavior, influencing immunomodulation and differentiation. Although a few in vivo studies exist, the majority of evidence comes from in vitro models. However, challenges remain for the clinical application of mesenchymal stem cell priming with phytocannabinoids or the secretome derived from primed cells. Standardized priming protocols, deeper mechanistic insights, and comprehensive in vivo validation are crucial to fully harness their therapeutic potential.
Citation	Ferreira LVO, de Oliveira PHD, Amorim RM. Phytocannabinoid-induced priming and differentiation of mesenchymal stem cells: Therapeutic potential. World J Stem Cells 2026; In press

Received	2025-11-21 05:03
Peer-Review Started	2025-11-21 05:03
First Decision by Editorial Office Director	2025-12-18 09:10
Return for Revision	2025-12-18 09:10
Revised	2025-12-27 12:20
Publication Fee Transferred
Second Decision by Editor	2026-02-02 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 09:26
Articles in Press	2026-02-09 09:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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