Publication Name	World Journal of Nephrology
Manuscript ID	116866
Country	Egypt

Category	Urology & Nephrology
Manuscript Type	Case Control Study
Article Title	Alpha-1-microglobulin as an early biomarker in renal extrahepatic manifestations of hepatitis C virus infection
Manuscript Source	Invited Manuscript
All Author List	Enas A R Alkareemy, Nashwa M Azoz, Ghada S Abdelnaiem, Rabea A Gadelkareem, Kawsar A Saleh and Essam M Abdel Aziz
Funding Agency and Grant Number
Corresponding Author	Rabea A Gadelkareem, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Egypt. rabeagad@aun.edu.eg
Key Words	Alpha-1-microglobulin; Hepatitis C virus; Kidney injury; Renal extrahepatic manifestations; Urinary biomarkers
Core Tip	Chronic hepatitis C virus (HCV) infection can lead to subclinical renal injury that often progresses unnoticed until chronic kidney disease develops. In this study, urinary alpha-1-microglobulin (Uα1M) proved to be a sensitive, early, and non-invasive biomarker for detecting tubular dysfunction in HCV-infected patients. The rate of elevated Uα1M levels correlated with subtle renal alterations and demonstrated strong diagnostic accuracy, even when traditional renal markers were within normal limits. Routine Uα1M assessment may facilitate early detection and intervention for HCV-related renal involvement, improving long-term renal outcomes.
Citation	Alkareemy EAR, Azoz NM, Abdelnaiem GS, Gadelkareem RA, Saleh KA, Abdel Aziz EM. Alpha-1-microglobulin as an early biomarker in renal extrahepatic manifestations of hepatitis C virus infection. World J Nephrol 2026; In press

Received	2025-11-24 04:21
Peer-Review Started	2025-11-24 04:21
First Decision by Editorial Office Director	2025-12-17 09:31
Return for Revision	2025-12-17 09:31
Revised	2025-12-21 21:13
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 01:05
Articles in Press	2026-02-03 01:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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