| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Impact of rebleeding after transjugular intrahepatic portosystemic shunt on liver related death based on liver function categories
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Yuan Zhu, Jun Tie, Yi-Fu Xia, Guang-Chuan Wang, Yu-Zheng Zhuge, Hao Wu, Xiao-Li Zhu, Hui Xue, Jiao Xu, Feng Zhang, Lian-Hui Zhao, Guang-Jun Huang, Ming-Yan Zhang, Zhen Li, Bo Wei, Pei-Jie Li, Ze Wang, Wei Wu, Chao Chen, Cheng-Wei Tang and Chun-Qing Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81970533 |
| National Key R&D Program of China |
No. 2023YFC2507505 |
| Natural Science Foundation of Shandong Province, China |
No. ZR2022ZD21 |
|
| Corresponding Author |
Chun-Qing Zhang, MD, PhD, Professor, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Jinan 250021, Shandong Province, China. zhangchunqing_sdu@163.com |
| Key Words |
Liver cirrhosis; Portal hypertension; Variceal rebleeding; Mortality; Transjugular intrahepatic portosystemic shunt |
| Core Tip |
Transjugular intrahepatic portosystemic shunt (TIPS) is considered a treatment option to prevent variceal rebleeding. However, the impact of post-TIPS rebleeding on mortality has not yet been investigated. Therefore, this study aimed to evaluate whether post-TIPS rebleeding increases liver-related mortality based on liver function categories in patients with cirrhosis. Our results suggest that post-TIPS rebleeding independently correlated with liver-related mortality, and it was significantly associated with higher liver-related mortality in patients with cirrhosis with variceal bleeding, irrespective of liver function category. Therefore, clinical management following TIPS should include a rigorous follow-up strategy, regardless of baseline Child-Pugh classification. |
| Citation |
Zhu JY, Tie J, Xia YF, Wang GC, Zhuge YZ, Wu H, Zhu XL, Xue H, Xu J, Zhang F, Zhao LH, Huang GJ, Zhang MY, Li Z, Wei B, Li PJ, Wang Z, Wu W, Chen C, Tang CW, Zhang CQ. Impact of rebleeding after transjugular intrahepatic portosystemic shunt on liver related death based on liver function categories. World J Gastroenterol 2026; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
