Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116881
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Inhibiting exosomal miR-191 can induce ferroptosis in macrophages, thereby delaying the progression of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Zi-Wei Wang, Li Jia, Ling-Ke Qu and Guo-Hua Gong
Funding Agency and Grant Number
Corresponding Author	Guo-Hua Gong, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn
Key Words	MicroRNA-191; Ferroptosis; Reactive oxygen species; Macrophage; Inflammation
Core Tip	Inhibiting miR-191 effectively suppresses macrophage M2 polarization by inducing the production of reactive oxygen species in colorectal cancer cells, triggering ferroptosis and subsequent apoptosis. Exosomal miR-191 may become a potential therapeutic target with significant implications for achieving precise diagnosis, precise treatment, and early disease prevention.
Citation	Wang ZW, Jia L, Qu LK, Gong GH. Inhibiting exosomal miR-191 can induce ferroptosis in macrophages, thereby delaying the progression of colorectal cancer. World J Gastrointest Oncol 2026; In press

Received	2025-11-24 03:22
Peer-Review Started	2025-11-24 05:40
First Decision by Editorial Office Director	2026-01-08 02:58
Return for Revision	2026-01-08 02:58
Revised	2026-01-12 07:47
Publication Fee Transferred
Second Decision by Editor	2026-02-11 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 06:14
Articles in Press	2026-02-11 06:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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