Publication Name	World Journal of Gastroenterology
Manuscript ID	116893
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Impact of computer-aided polyp detection in screening and diagnostic colonoscopy: A multicenter randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Gian Eugenio Tontini, Lorenzo Dioscoridi, Raffaele Salerno, Giovanni Aldinio, Matteo Rossano Buonocore, Paola Cesaro, Francesco Conforti, Dario Consonni, Irene Cottone, Emanuele Dabizzi, Beatrice Mantia, Fabio Monica, Massimiliano Mutignani, Nicola Olivari, Giulia Picardi, Daniele Salvi, Lucia Scaramella, Mario Schettino, Matilde Topa, Maurizio Vecchi and Luca Elli
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Education and Research - MUR Italian Ministry of Health RC2026/150/01
Corresponding Author	Gian Eugenio Tontini, Assistant Professor, MD, PhD, Department of Pathophysiology and Organ Transplantation, University of Milan, Via della Commenda 19, Milan 20122, Lombardy, Italy. gianeugenio.tontini@unimi.it
Key Words	Artificial intelligence; Image processing; Computer-assisted; Colorectal neoplasms; Colonoscopy; Intestinal polyps
Core Tip	This study shows that in tertiary centers, computer-aided detection (CADe) did not enhance overall polyp or adenoma detection compared with conventional, ultra-high-definition colonoscopy. High-volume endoscopists did not benefit and in some cases performed slightly worse with CADe. Indicators of operator fatigue did not significantly influence CADe effectiveness.
Citation	Tontini GE, Dioscoridi L, Salerno R, Aldinio G, Buonocore MR, Cesaro P, Conforti F, Consonni D, Cottone I, Dabizzi E, Mantia B, Monica F, Mutignani M, Olivari N, Picardi G, Salvi D, Scaramella L, Schettino M, Topa M, Vecchi M, Elli L. Impact of computer-aided polyp detection in screening and diagnostic colonoscopy: A multicenter randomized controlled trial. World J Gastroenterol 2026; In press

Received	2025-11-24 07:09
Peer-Review Started	2025-11-24 07:09
First Decision by Editorial Office Director	2026-01-12 09:15
Return for Revision	2026-01-12 09:15
Revised	2026-02-13 21:55
Publication Fee Transferred	2026-03-06 10:18
Second Decision by Editor	2026-04-22 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-22 06:43
Articles in Press	2026-04-22 06:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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