Publication Name	World Journal of Clinical Oncology
Manuscript ID	116895
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Yin Yang 1 in inflammatory memory and progression susceptibility in Helicobacter pylori–associated gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Fan Wei
Funding Agency and Grant Number
Corresponding Author	Meng-Fan Wei, Zhejiang Chinese Medical University, School of Medical Technology and Information Engineering, Puyan Street, Binjiang District, Hangzhou City, Zhejiang Province Binwen Campus of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China. 202312210701027@zcmu.edu.cn
Key Words	Helicobacter pylori; Gastric cancer; Yin Yang 1; Janus kinase 2-signal transducer and activator of transcriptional protein 3 signaling; Epithelial-mesenchymal transition; Inflammatory memory; Progression susceptibility; Epigenetic imprinting
Core Tip	This commentary discusses the study by Chen et al, which demonstrated that Yin Yang 1 (YY1) mediates Helicobacter pylori (H. pylori)-induced activation of the Janus kinase 2-signal transducer and activator of transcriptional protein 3 pathway and epithelial-mesenchymal transition in gastric cancer. By Integrating recent work on innate and epithelial inflammatory memory with the broader biology of YY1 in malignancy, this article propose that sustained and heterogeneous upregulation of YY1 upregulation may represent an inflammation-derived transcriptional imprint and an early determinant of progression susceptibility. These insights open new directions for risk stratification and pathway-targeted prevention in H. pylori-infected individuals.
Citation	Wei MF. Yin Yang 1 in inflammatory memory and progression susceptibility in Helicobacter pylori–associated gastric cancer. World J Clin Oncol 2026; In press

Received	2025-11-24 05:46
Peer-Review Started	2025-11-24 05:46
First Decision by Editorial Office Director	2025-12-03 08:00
Return for Revision	2025-12-06 15:29
Revised	2025-12-16 11:03
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 13:33
Articles in Press	2026-02-02 13:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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