Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116896
Country	Türkiye

Category	Biochemistry & Molecular Biology
Manuscript Type	Letter to the Editor
Article Title	GEN1 as a potential therapeutic target in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yusuf Tutar
Funding Agency and Grant Number
Corresponding Author	Yusuf Tutar, Chairman, Dean, Tenured Professor, Department of Basic Medical Sciences, Division of Medicinal Biochemistry, Recep Tayyip Erdogan University, Islampaşa, Rize 53020, None Selected, Türkiye. yusuf.tutar@erdogan.edu.tr
Key Words	GEN1; Gastric cancer; Ferroptosis; Mitochondrial dysfunction; Cell cycle; Chemotherapy sensitivity
Core Tip	Gastric cancer (GC) growth is driven by complex molecular pathways including genomic instability, cell cycle dysregulation, mitochondrial dysfunction, and ferroptosis. Novel data suggest that GEN1, a Holliday junction resolvase involved in DNA repair, is a key oncogenic regulator in GC that promotes tumor cell proliferation, migration, survival, and chemoresistance, and modulates ferroptosis-related pathways, suggesting that GEN1 may be a therapeutic target and that adding molecular markers related to DNA damage responses may enhance diagnostic accuracy and therapy stratification in GC.
Citation	Tutar Y. GEN1 as a potential therapeutic target in gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2025-11-24 06:14
Peer-Review Started	2025-11-24 07:28
First Decision by Editorial Office Director	2025-12-23 10:02
Return for Revision	2025-12-23 10:02
Revised	2026-01-06 05:56
Publication Fee Transferred
Second Decision by Editor	2026-01-19 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-19 04:51
Articles in Press	2026-01-19 04:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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