Publication Name	World Journal of Methodology
Manuscript ID	116914
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Low-energy fractional carbon dioxide laser priming of mesenchymal stem cells-exosomes: A photothermal boost for diabetic wound angiogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Jin Wu, Ju-Yu Tang and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author	Nian-Zhe Sun, MD, PhD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Kaifu District, Changsha, Hunan, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words	Diabetic wound; Fractional carbon dioxide laser; Photothermal preconditioning; Sphingosine-1-phosphate; Acellular therapy
Core Tip	Chen et al demonstrate that fractional carbon dioxide laser-induced photothermal stimulation enhances the biological activity of mesenchymal stem cell-derived exosomes by enriching sphingosine-1-phosphate content and activating the S1PR1/AKT/HIF-1α pathway. These laser-activated exosomes significantly promote endothelial angiogenesis and accelerate diabetic wound healing in vivo. This study introduces a safe, controllable, and clinically accessible strategy for optimizing exosome-based acellular therapies in chronic diabetic wounds.
Citation	Wu XJ, Tang JY, Sun NZ. Low-energy fractional carbon dioxide laser priming of mesenchymal stem cells-exosomes: A photothermal boost for diabetic wound angiogenesis. World J Methodol 2026; In press

Received	2025-11-25 03:19
Peer-Review Started	2025-11-25 03:41
First Decision by Editorial Office Director	2026-01-06 06:26
Return for Revision	2026-01-06 11:51
Revised	2026-01-09 09:45
Publication Fee Transferred
Second Decision by Editor	2026-01-22 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-22 05:49
Articles in Press	2026-01-22 05:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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