Publication Name	World Journal of Orthopedics
Manuscript ID	116916
Country	India

Category	Orthopedics
Manuscript Type	Randomized Controlled Trial
Article Title	Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells in knee osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Harish V K Ratna, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nādu, India. madhanjeyaraman@gmail.com
Key Words	Osteoarthritis; Peripheral blood; Peripheral blood-derived mesenchymal stromal cells; Regenerative therapy; Cartilage Regeneration; Randomized controlled trial
Core Tip	Optimizing delivery routes for peripheral blood-derived mesenchymal stromal cells is key to enhancing regenerative outcomes in early-grade knee osteoarthritis. This trial compares intra-articular, subchondral, and combined injection techniques using clinical scores and advanced imaging over 12 months. The goal is to establish minimally invasive, evidence-based protocols that improve function, reduce pain, and delay progression - aligned with the Indian healthcare context and regenerative medicine advancements.
Citation	Ratna HVK, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells in knee osteoarthritis. World J Orthop 2026; In press

Received	2025-11-25 04:01
Peer-Review Started	2025-11-25 04:01
First Decision by Editorial Office Director	2025-12-17 09:02
Return for Revision	2025-12-17 09:02
Revised	2025-12-23 06:30
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 08:02
Articles in Press	2026-02-09 08:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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