Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	116918
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Exploring the mechanism and potential treatment of severe acute pancreatitis-associated lung injury based on the gut-lung axis
Manuscript Source	Invited Manuscript
All Author List	Xin-Tong Ye, Chu-Ying Yu, Hao-Yu Zhao, Su-Ting Qian, Ye Huang and Qing-Sheng Liu
Funding Agency and Grant Number
Corresponding Author	Qing-Sheng Liu, Chief Physician, Department of Gastroenterology, Third People’s Hospital of Hangzhou, No. 453 Stadium Road, Hangzhou 310009, Zhejiang Province, China. 7394822@qq.com
Key Words	Severe acute pancreatitis-associated acute lung injury; Gut-lung axis; Intestinal microbiota; Bacterial translocation; Migration of immune cells
Core Tip	Severe acute pancreatitis (SAP)-associated acute lung injury is a pivotal determinant of mortality. The gut-lung axis plays a central role in its pathogenesis: SAP-induced gut microbiota dysbiosis compromises the intestinal barrier, facilitating bacterial/endotoxin translocation and gut-derived immune cell migration to the lungs. This process culminates in a profound pulmonary inflammatory response, thereby identifying the gut-lung axis as a promising therapeutic target for novel interventions against SAP-associated acute lung injury.
Citation	Ye XT, Yu CY, Zhao HY, Qian ST, Huang Y, Liu QS. Exploring the mechanism and potential treatment of severe acute pancreatitis-associated lung injury based on the gut-lung axis. World J Gastrointest Surg 2026; In press

Received	2025-11-25 03:48
Peer-Review Started	2025-11-25 03:48
First Decision by Editorial Office Director	2025-12-05 09:11
Return for Revision	2025-12-05 09:11
Revised	2025-12-18 14:16
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 07:46
Articles in Press	2026-02-02 07:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com