Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	116949
Country	China

Category	Behavioral Sciences
Manuscript Type	Prospective Study
Article Title	Upper gastrointestinal endoscopic screening serves as a primary prevention approach by reducing modifiable risk factors
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Wen Cheng, Zhen Liu, Chuan-Hai Guo, Feng-Lei Li, Ya-Qi Pan, Ying Liu, Fang-Fang Liu, Huan-Yu Chen, Wen-Lei Yang, Hong-Rui Tian, Chao Shi, Zhong-Hu He, Meng-Fei Liu and Yang Ke
Funding Agency and Grant Number	Funding Agency Grant Number Key R&D Program of Ningxia Hui Autonomous Region No. 2025BEG01011 Science and Technology Plan of Tibet Autonomous Region No. XZ202501JD0021
Corresponding Author	Meng-Fei Liu, PhD, Professor, Department of Genetics, Peking University Cancer Hospital, No. 52 Fucheng Road, Haidian District, Beijing 100142, Beijing, China. liumengfei1205@foxmail.com
Key Words	Upper gastrointestinal tract cancer; Endoscopic screening; Risk factors; Primary prevention; Health promotion
Core Tip	This study provides novel evidence that upper gastrointestinal (UGI) endoscopic screening contributes to primary cancer prevention by reducing modifiable risk factors. Based on a population-based randomized controlled trial, we showed that UGI screening significantly promoted the reduction of cigarette smoking, alcohol drinking, and unhealthy dietary habits, particularly among women and older adults. These findings highlight the potential of UGI endoscopic screening to modify behavioral risk factors at the population level, underscoring its broader preventive value in cancer control strategies. Integrating health education into UGI screening programs may further enhance its effectiveness in reducing the cancer burden.
Citation	Cheng XW, Liu Z, Guo CH, Li FL, Pan YQ, Liu Y, Liu FF, Chen HY, Yang WL, Tian HR, Shi C, He ZH, Liu MF, Ke Y. Upper gastrointestinal endoscopic screening serves as a primary prevention approach by reducing modifiable risk factors. World J Gastrointest Oncol 2026; In press

Received	2025-11-26 03:29
Peer-Review Started	2025-11-26 03:29
First Decision by Editorial Office Director	2025-12-30 05:47
Return for Revision	2025-12-30 05:47
Revised	2026-01-14 01:59
Publication Fee Transferred	2026-01-16 03:06
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 09:05
Articles in Press	2026-02-09 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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