Publication Name	World Journal of Gastroenterology
Manuscript ID	116951
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Unveiling a novel vitamin D receptor signaling pathway for allyl isothiocyanate against metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ming Liu, Chun Guo, Peng Zhang and Shang-Ming Liu
Funding Agency and Grant Number
Corresponding Author	Peng Zhang, Medical Basic Experiment Teaching Center, School of Basic Medical Sciences, Shandong University, No. 44, Wenhua Xi Road, Lixia District, Jinan 250012, Shandong Province, China. zhangpeng1990@sdu.edu.cn
Key Words	Allyl isothiocyanate; Metabolic dysfunction-associated steatotic liver disease; Vitamin D receptor; Lipid metabolism; Fatty acid β-oxidation; Insulin resistance
Core Tip	Gao et al identify a novel pathway for allyl isothiocyanate-mediated improvement of metabolic dysfunction-associated steatotic liver disease, involving the activation of the vitamin D receptor (VDR) signaling pathway in hepatocytes. We further propose that transient receptor potential ankyrin 1-mediated calcium signaling may act upstream of VDR activation, offering an alternative mechanistic insight. Future work needs to give priority to validating causality, particularly through VDR-knockout models and well-characterized in vivo models, such as high-fat diet or genetic metabolic dysfunction-associated steatotic liver disease models. This would allow researchers to evaluate the impact of allyl isothiocyanate, which is crucial for therapeutic translation.
Citation	Liu M, Guo C, Zhang P, Liu SM. Unveiling a novel vitamin D receptor signaling pathway for allyl isothiocyanate against metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; In press

Received	2025-11-28 01:09
Peer-Review Started	2025-11-28 05:57
First Decision by Editorial Office Director	2025-12-09 10:06
Return for Revision	2025-12-09 10:06
Revised	2025-12-15 06:44
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 02:12
Articles in Press	2026-02-03 02:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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