Publication Name	World Journal of Gastroenterology
Manuscript ID	116953
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	From clinical efficacy to population health: Implementing vonoprazan-amoxicillin dual therapy for Helicobacter pylori control
Manuscript Source	Invited Manuscript
All Author List	Qing Chen, Kang-Ning Li and Tian-Qi Liu
Funding Agency and Grant Number	Funding Agency Grant Number Medical and Health Appropriate Technology Development and Promotion Project of the Health Commission of Guangxi Zhuang Autonomous Region No. S2023034
Corresponding Author	Tian-Qi Liu, Consultant, MD, PhD, Professor, Department of General Surgery, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, No. 85 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. ljrqt@126.com
Key Words	Helicobacter pylori; Vonoprazan; Amoxicillin; Dual therapy; Eradication treatment; Public health; Pharmacoeconomics; Antibiotic resistance
Core Tip	This editorial highlights vonoprazan-amoxicillin dual therapy, particularly the 0.5 g four-times-daily regimen, as a highly effective, safe, and well-tolerated strategy for Helicobacter pylori eradication, based on a recent large-scale regional trial. Its exceptional cost-effectiveness, high patient compliance, and dosing simplicity position it as a transformative candidate for large-scale public health interventions that aimed at reducing the burden of Helicobacter pylori-associated diseases, including gastric cancer. Successful implementation, however, necessitates addressing challenges such as antimicrobial resistance surveillance and ensuring equitable access to healthcare systems.
Citation	Chen Q, Li KN, Liu TQ. From clinical efficacy to population health: Implementing vonoprazan-amoxicillin dual therapy for Helicobacter pylori control. World J Gastroenterol 2026; In press

Received	2025-11-25 03:25
Peer-Review Started	2025-11-25 03:26
First Decision by Editorial Office Director	2025-12-16 09:59
Return for Revision	2025-12-16 09:59
Revised	2025-12-29 02:10
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 09:55
Articles in Press	2026-01-09 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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