Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	116958
Country	Brazil

Category	Immunology
Manuscript Type	Observational Study
Article Title	Helicobacter pylori eradication is associated with systemic anti-inflammatory shift in duodenal ulcer patients compared to those with gastritis
Manuscript Source	Invited Manuscript
All Author List	Fabrício Freire de Melo, Fabian Fellipe Bueno Lemos, Rafael Augusto Oliveira Sodré Leal, Gifone Aguiar Rocha and Dulciene Maria de Magalhães Queiroz
Funding Agency and Grant Number
Corresponding Author	Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Key Words	Helicobacter pylori; Cytokines; Gastritis; Duodenal ulcer; Treatment
Core Tip	Helicobacter pylori (H. pylori) infection is consistently associated with chronic gastric inflammation and may also relate to sustained low-grade systemic inflammatory activity. In this study, distinct circulating cytokine patterns were observed in patients with gastritis (GA) and duodenal ulcer (DU) following bacterial eradication, with attenuation of pro-inflammatory mediators in GA and a regulatory-skewed cytokine profile in DU. These findings highlight a potential systemic immunological dimension of H. pylori-associated disease, with relevance for inflammation-related conditions beyond the gastric compartment.
Citation	de Melo FF, Lemos FFB, Leal RAOS, Rocha GA, de Magalhães Queiroz DM. Helicobacter pylori eradication is associated with systemic anti-inflammatory shift in duodenal ulcer patients compared to those with gastritis. World J Gastrointest Endosc 2026; In press

Received	2025-11-25 03:59
Peer-Review Started	2025-11-25 07:22
First Decision by Editorial Office Director	2025-12-24 10:36
Return for Revision	2025-12-25 22:52
Revised	2026-01-07 20:48
Publication Fee Transferred
Second Decision by Editor	2026-01-21 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 03:02
Articles in Press	2026-01-21 03:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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