Publication Name	World Journal of Nephrology
Manuscript ID	116961
Country	Egypt

Category	Urology & Nephrology
Manuscript Type	Prospective Study
Article Title	Early detection of contrast-associated acute kidney injury after coronary angiography: A predictive value of osteopontin
Manuscript Source	Invited Manuscript
All Author List	Nashwa M Azoz, Noura G Nasr, Mohamad A Sobh, Ahmed Abdel-Galeel, Randa A Elzohne, Rabea A Gadelkareem and Alaa O Ahmed
Funding Agency and Grant Number	Funding Agency Grant Number the Grants Office, Faculty of Medicine, Assiut University (Egypt) 2022-09-25-001
Corresponding Author	Rabea A Gadelkareem, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71711, Egypt. rabeagad@aun.edu.eg
Key Words	Acute kidney injury; Contrast; Contrast-associated acute kidney injury; Coronary angiography; Nephropathy; Osteopontin
Core Tip	Serum osteopontin (OPN) is a strong and independent biomarker for predicting contrast-associated acute kidney injury after percutaneous coronary intervention. Its combination with the Mehran risk score offers the highest diagnostic accuracy. The current study presents novel evidence that OPN levels, measured before and after percutaneous coronary intervention, are significantly elevated in patients with contrast-associated acute kidney injury, identifying OPN as one of the most robust and independent predictors (alongside the Mehran score and contrast volume). Integrating OPN with the Mehran score yielded a diagnostic accuracy of 88%, suggesting that OPN should be incorporated into risk stratification strategies for timely preventive interventions.
Citation	Azoz NM, Nasr NG, Sobh MA, Abdel-Galeel A, Elzohne RA, Gadelkareem RA, Ahmed AO. Early detection of contrast-associated acute kidney injury after coronary angiography: A predictive value of osteopontin. World J Nephrol 2026; In press

Received	2025-11-25 04:04
Peer-Review Started	2025-11-25 04:04
First Decision by Editorial Office Director	2025-12-09 09:27
Return for Revision	2025-12-09 09:27
Revised	2025-12-20 23:23
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 06:09
Articles in Press	2026-02-02 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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