Publication Name	World Journal of Radiology
Manuscript ID	116973
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Prospective Study
Article Title	Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy
Manuscript Source	Unsolicited Manuscript
All Author List	Wan-Li Zhuang, Shang-Wen Xu, Jian Fang, Zhi-Qiang Zhang, Shi-An Zhang, Jie-Long Wang, Jiao-Long Zheng, Xiao-Yang Wang and Dong-Liang Li
Funding Agency and Grant Number	Funding Agency Grant Number Guiding Projects of Social Development of Fujian Province 2021Y0062 Natural Science Foundation of Fujian Province of China 2024J011172
Corresponding Author	Dong-Liang Li, MD, PhD, Professor, Department of Hepatobiliary Disease, The 900th Hospital of PLA Joint Logistic Support Force, No. 156 West Second Ring Road North, Fuzhou 350025, Fujian Province, China. dongliangli93@163.com
Key Words	Hepatic encephalopathy; Transjugular intrahepatic portosystemic shunt; Cerebral blood flow; Arterial spin labeling; Resting-state functional magnetic resonance imaging
Core Tip	Using three-dimensional arterial spin labeling and resting-state functional magnetic resonance imaging, we dynamically evaluated cerebral blood flow and spontaneous brain activity in cirrhotic patients undergoing (transjugular intrahepatic portosystemic shunts) TIPS. We demonstrated region-specific cerebral blood flow and amplitude of low-frequency fluctuation alterations after TIPS that correlated with changes in Child-Pugh score, portal pressure gradient and neuropsychological performance. These findings indicate that postoperative cerebral hemodynamic changes, together with hyperammonemia, may contribute to hepatic encephalopathy and that resting-state functional magnetic resonance imaging is a sensitive tool for detecting early or mild cognitive impairment after TIPS.
Citation	Zhuang WL, Xu SW, Fang J, Zhang ZQ, Zhang SA, Wang JL, Zheng JL, Wang XY, Li DL. Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy. World J Radiol 2026; In press

Received	2025-11-26 07:24
Peer-Review Started	2025-11-26 07:24
First Decision by Editorial Office Director	2025-12-03 10:12
Return for Revision	2025-12-03 10:12
Revised	2025-12-08 13:39
Publication Fee Transferred	2025-12-13 12:00
Second Decision by Editor	2026-01-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-13 09:22
Articles in Press	2026-01-13 09:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8470 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com