Publication Name	World Journal of Hepatology
Manuscript ID	117012
Country	United States

Category	Transplantation
Manuscript Type	Editorial
Article Title	Hepatic ischemia reperfusion injury: Understanding the little components of the larger picture
Manuscript Source	Invited Manuscript
All Author List	Eyad Abdulrazzak and Eric R Kallwitz
Funding Agency and Grant Number
Corresponding Author	Eric R Kallwitz, Associate Professor, Division of Hepatology, Department of Medicine, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, United States. ekallwitz@lumc.edu
Key Words	Surgical complications; Liver allograft; Hepatocellular injury; Ischemia prevention; Organ preservation
Core Tip	Despite advancements in surgical techniques and preservation, hepatic ischemia-reperfusion injury (H-IRI) remains a critical hurdle in liver transplantation, contributing to early allograft dysfunction. While machine perfusion represents a major macro-level advancement, pharmacological strategies targeting specific molecular pathways remain an important avenue for mitigating H-IRI. This editorial briefly outlines the complexity of H-IRI mechanisms, discusses emerging pharmacological and mechanical interventions, and highlights recent findings on the neurokinin-1 receptor antagonist aprepitant as a potential therapeutic agent.
Citation	Abdulrazzak E, Kallwitz ER. Hepatic ischemia reperfusion injury: Understanding the little components of the larger picture. World J Hepatol 2026; In press

Received	2025-11-26 02:33
Peer-Review Started	2025-11-26 02:33
First Decision by Editorial Office Director	2025-12-24 10:14
Return for Revision	2025-12-24 10:14
Revised	2026-01-02 18:28
Publication Fee Transferred
Second Decision by Editor	2026-04-01 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 12:18
Articles in Press	2026-04-01 12:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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