Publication Name	World Journal of Nephrology
Manuscript ID	117015
Country	Nigeria

Category	Urology & Nephrology
Manuscript Type	Prospective Study
Article Title	Pediatric cardiac surgery associated-acute kidney injury: Interleukin 18 as a new biomarker
Manuscript Source	Invited Manuscript
All Author List	Ronke Adunni Makinde, Abiodun Olabamiji Ajose, Abiodun Kofoworola Ajeigbe, Tewogbade Adeoye Adedeji, Uvie Ufuoma Onakpoya and Olugbenga Olalekan Ojo
Funding Agency and Grant Number
Corresponding Author	Ronke Adunni Makinde, Consultant, Principal Investigator, Researcher, Department of Chemical Pathology, Obafemi Awolowo University Teaching Hospital Complex, Ilesa Road, Ile ife 220282, Osun, Nigeria. ronkeomoola@yahoo.com
Key Words	Interleukin 18; Creatinine; Pediatric; Acute kidney injury; Cardiac surgery; Receiver operating characteristic curve
Core Tip	In the present study, we have shown that interleukin 18 had an earlier rise than the traditional creatinine in those patients who developed cardiac surgery associated acute kidney injury after open heart surgery, and that it is also a better diagnostic marker with its superior area under the curve value on receiver operating characteristic curve than creatinine, thus, our findings underscore the importance of using this biomarker in the diagnosis of cardiac surgery associated acute kidney injury for earlier diagnosis and improved patient outcome.
Citation	Makinde RA, Ajose AO, Ajeigbe AK, Adedeji TA, Onakpoya UU, Ojo OO. Pediatric cardiac surgery associated-acute kidney injury: Interleukin 18 as a new biomarker. World J Nephrol 2026; In press

Received	2025-11-27 01:12
Peer-Review Started	2025-11-27 01:12
First Decision by Editorial Office Director	2025-12-11 09:38
Return for Revision	2025-12-11 09:38
Revised	2025-12-24 12:35
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 12:57
Articles in Press	2026-02-06 12:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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