Publication Name	World Journal of Experimental Medicine
Manuscript ID	117024
Country	India

Category	Biochemical Research Methods
Manuscript Type	Review
Article Title	Very low-density lipoprotein and the human health
Manuscript Source	Invited Manuscript
All Author List	Alok Bharadwaj, Manas Taneja, Sneha Dubey and Aditya Saxena
Funding Agency and Grant Number
Corresponding Author	Alok Bharadwaj, Associate Professor, PhD, Department of Biotechnology, GLA University, 17 Kilometre Mile Stone, Mathura-Delhi Highway NH-1, Mathura 281406, Uttar Pradesh, India. alok.bhardwaj@gla.ac.in
Key Words	Very low-density lipoprotein metabolism; Physiological health; Pathological function; Lipids; Cholesterol; High blood pressure-based cardiovascular disease
Core Tip	The liver secretes very low-density lipoprotein (VLDL), implicated in diseases such as atherosclerosis, metabolic-associated fatty liver disease, cognitive impairment, metabolic syndrome, autoimmune disorders, breast cancer, and head and neck cancer. VLDL contributes to atrial myopathy in the preclinical stage of atrial fibrillation and exhibits cytotoxic effects in myocardial infarction, though the mechanism remains unclear. Endocrine disorders can alter VLDL levels, and VLDL has been shown to increase aldosterone production. Its pathogenic role extends to extrahepatic release, neurological disorders, sleep disturbances, and various malignancies. Understanding VLDL regulation and metabolism, rather than just its levels, may clarify its role in disease and guide targeted therapeutic strategies.
Citation	Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; In press

Received	2025-11-27 01:06
Peer-Review Started	2025-11-27 07:31
First Decision by Editorial Office Director	2025-12-09 08:50
Return for Revision	2025-12-09 08:50
Revised	2025-12-23 10:40
Publication Fee Transferred
Second Decision by Editor	2026-02-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 07:35
Articles in Press	2026-02-12 07:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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